Isak ran onto a gorgeous through ball by Florian Wirtz and buried a shot past Guglielmo Vicario while Micky van de Ven slid through the Swedish striker.
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The 26-year-old was in clear distress and did not celebrate his goal after his left ankle was caught between the cutting legs of Van de Ven.
He needed to be helped from the Tottenham Hotspur Stadium pitch for Jeremie Frimpong in the 60th minute.
Isak’s strike partner Hugo Ekitike was not happy with Van de Ven’s desperate challenge to block the goal.
“It was very physical today, a lot of duels,” Ekitike said. “Sometimes it wasn’t football and a bit too much like when you see what happened with Alex. But that’s part of football. It was a great war and we won.”
Liverpool boss Arne Slot did not have much of an update after the game.
“Difficult so short after the game to know what he exactly he has but it’s never a nice thing,” Slot said after the game. “Hopefully he’s fine but we have to wait and see.”
Alexander Isak injury history: Star suffers distressing injury while scoring for Liverpool
The striker has suffered a number of injuries since arriving in England.
Isak was pretty durable for Real Sociedad but lost time early in his first season with Newcastle. The Swede scored twice in his first three Premier League games before missing 11 with a thigh problem.
His second season at St. James’ Park saw two separate three-game absences with groin ailments, but a broken toe only cost him two matches last season as he played 34 PL games for the Magpies.
Hopefully this injury isn’t as bad as it appeared on camera.
