Chiefs vs. Jaguars 2025 Prediction, Odds, Picks – Oct 6

The Kansas City Chiefs (2-2) are considered favorites (-3.5) according to the bookmakers ahead of their game versus the Jacksonville Jaguars (3-1) on October 6, 2025, starting at 8:15 p.m. ET, airing on ABC/ESPN. The game has an over/under of 45.5 points.

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Chiefs vs. Jaguars Odds & Betting Lines

Chiefs vs. Jaguars Prediction & Pick

• Pick ATS: Jaguars (+3.5)
  
• Pick OU: Under (45.5)
  
• Prediction: Jaguars 22 – Chiefs 21

How to Watch Kansas City vs. Jacksonville

• Game date: Monday, October 6, 2025
• Time: 8:15 p.m. ET
• Venue: EverBank Stadium
• Location: Jacksonville, Florida
• TV: ABC/ESPN
• Live Boxscore: FOX Sports

Chiefs vs. Jaguars Recent Matchups

• In their past five head-to-head matchups, Kansas City has beaten Jacksonville five times.
• In their last five head-to-head matchups, Kansas City has scored 141 points versus Jacksonville, while surrendering only 86 points.

Kansas City Betting Info

• Kansas City has two wins versus the spread in four games this year.
• The Chiefs have been favored by 3.5 points or more two times this season, and covered the spread in one of those matchups.
• Kansas City games this year have gone over the total in two out of four opportunities (50%).
• The Chiefs have been moneyline favorites in two other matchups this season, and they split them.
• The implied probability for this matchup, considering the moneyline, gives the Chiefs a 66.4% chance to win.

Chiefs Stats

Kansas City’s Key Players

Offense

• Patrick Mahomes has 939 passing yards (10th in the NFL), seven touchdowns (ninth in the NFL) and one interception this year. He has completed 61.3% of his passes, averaging 234.8 yards per game and 6.6 per attempt.
• He has also rushed for 130 yards (first on the Chiefs) and added two touchdowns on the ground, while averaging 32.5 rushing yards per game.
• Tyquan Thornton has caught 10 passes on 20 targets for 182 total yards and three touchdowns. He is averaging 2.5 catches and 45.5 yards per game through four games.
• In the passing attack, Marquise Brown, has totaled 209 receiving yards and one touchdown after hauling in 22 balls on 32 targets. Per game, he’s averaging 52.3 yards and 5.5 receptions in four games.
• Travis Kelce has 15 catches for 182 yards and one touchdown. He’s been targeted 22 times in the passing game, and averages 3.8 receptions and 45.5 yards in four games played.

Defense

• On defense, George Karlaftis III has 18 tackles, six TFL, three sacks, and one pass defended in 2025.
• Drue Tranquill has 24 tackles, two TFL, and two sacks.
• Nick Bolton has collected 34 tackles and two TFL this year. His tackle total leads the Chiefs.
• Chamarri Conner has 27 tackles on the season.

Jacksonville Betting Info

• Jacksonville has registered a 3-1-0 record against the spread this season.
• This year, the Jaguars have one against-the-spread win in two games as an underdog of 3.5 points or more.
• Jacksonville games have gone over the total twice this year.
• The Jaguars have split the two games they’ve played as underdogs this season.
• The implied probability of a win by the Jaguars based on the moneyline is 37.9%.

Jaguars Stats

Jacksonville’s Key Players

Offense

• Travis Etienne averages 98.5 rushing yards per game this year (394 total yards to rank third in the NFL), while scoring two rushing touchdowns.
• Etienne’s offensive contributions include six receptions (1.5 per game) on 10 targets for 32 yards (8 per game) and one receiving touchdown.
• Trevor Lawrence has 845 passing yards, five touchdowns and four interceptions. His completion percentage is 58.3% and he averages 211.3 yards per game and 5.9 per attempt.
• Bhayshul Tuten has rushed for one touchdown this year, and has totaled 88 rushing yards (22 per game and 4.2 per carry).
• In addition to his rushing stats, Tuten has hauled in three passes (on four targets) for 40 yards (seventh on the Jaguars), with one receiving touchdown. He averages 10 yards per game.
• Brian Thomas has 164 receiving yards from 12 receptions after receiving 32 targets.

Defense

• In 2025, Foyesade Oluokun has one sack to go with two TFL, 30 tackles, and one interception through four games.
• Devin Lloyd has two TFL, 17 tackles, and three interceptions through four games.
• Jourdan Lewis has intercepted two passes on top of 19 tackles, three TFL, and six passes defended during the 2025 campaign. His interception total ranks fourth in the NFL.
• Tyson Campbell has totaled one TFL and 27 tackles over four games.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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