Cincinnati is favored by -21.5 points on the spread with a moneyline of -2000. The total is set at 57.5 points.
Here’s my Cincinnati vs. Oklahoma State predictions and college football picks for Saturday, October 18, 2025.
Cincinnati vs. Oklahoma State Pick: Cincinnati -21.5
My Oklahoma State vs. Cincinnati best bet is on the Bearcats to cover the spread. Find the best line available on our live NCAAF odds page.
Cincinnati vs Oklahoma State Odds, Spread
8 p.m. ET
ESPN2
| Cincinnati Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-21.5 -110 | 57.5 -115o / -105u | -2000 |
| Oklahoma State Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+21.5 -110 | 57.5 -115o / -105u | +1000 |
- Cincinnati vs Oklahoma State point spread: Cincinnati -21.5
- Cincinnati vs Oklahoma State over/under: 57.5 points
- Cincinnati vs Oklahoma State moneyline: Cincinnati -2000, Oklahoma State +1000
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This season has become a lost cause for Oklahoma State. Not only did the Cowboys fire their head coach Mike Gundy, but they’ve lost five games in a row by an average of 28.2 points per outing.
Now they have No. 24 Cincinnati coming to town, and it’s not expected to be pretty, according to a system backed by our very own Evan Abrams.
Abrams has a system called “The Right Favorite” that predicts Cincinnati will cover the 21.5-point spread. This system is +13,420 with a 11.6% return on investment (ROI) since its inception in 2005. Also, this season alone, it’s 10-6 with a 20% ROI.
“The Right Favorite” is a college football system built on recognizing when the betting market underestimates a favorite.
In the regular season, when an opponent is coming off a loss by seven to 23 points, perception often inflates their chances of rebounding, yet those weaknesses typically carry into the next game.
By focusing on contests where the total is set between 55 and 100, the system narrows in on games expected to have higher scoring, which makes it more difficult for struggling teams to keep pace.
Limiting the sample to the first 11 games ensures the analysis applies before postseason adjustments in motivation and preparation occur.
Finally, the spread filter targets situations where the line is set with the other side catching points, but not in extreme ranges, allowing favorites to deliver consistent covers.
Together, these conditions create a profile where the favorite is positioned as the stronger play despite public bias suggesting otherwise.
Pick: Cincinnati -21.5
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