NFL Week 5 betting odds and lines: Chiefs are Monday Night Football road favorites in Jacksonville

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NFL Week 5 betting odds and lines: Chiefs are Monday Night Football road favorites in Jacksonville


NFL’s Week 5 slate gets underway with a matchup of NFC West rivals when the San Francisco 49ers visit the Los Angeles Rams on “Thursday Night Football.” The line had opened at Rams -3.5 before injuries (including to Brock Purdy) moved it all the way up to -8.5.

There will be an early Sunday football again this week as Dillon Gabriel makes his NFL debut in London, England for the Cleveland Browns as they face the Minnesota Vikings, playing the second leg of their two-game European road trip.

Lines have moved for Denver Broncos at Philadelphia Eagles, as well as for Houston Texans at Baltimore Ravens, though the latter can be attributed to expectations that Cooper Rush will be starting for the Ravens due to Lamar Jackson’s injury.

Sunday night features another division rivalry when the Buffalo Bills host the New England Patriots.

The week wraps up with the Kansas City Chiefs hitting the road to take on the Jacksonville Jaguars on “Monday Night Football” (8:15 p.m. ET on ABC/ESPN).

Bye weeks also begin, with the Atlanta Falcons, Chicago Bears, Green Bay Packers and Pittsburgh Steelers all off this weekend.

Here’s a look at the odds for every Week 5 game.

Odds as of publication time. For the most current odds, visit ESPN BET.

Jump to:
SF-LAR | MIN-CLE | LV-IND | DAL-NYJ
DEN-PHI | MIA-CAR | HOU-BAL | NYG-NO
TEN-ARI | TB-SEA | WSH-LAC | DET-CIN
NE-BUF | KC-JAX


San Francisco 49ers vs. Los Angeles Rams -8.5
Thursday, 8:15 p.m., Prime Video


Line movement: Opened Rams -3.5

Money Line: 49ers (+340); Rams (-450)
Total: 44.5; Opened: 46.5
FPI favorite: Rams by 8.6 with a 72.13% probability to win the game outright


Minnesota Vikings -3.5 vs. Cleveland Browns
Sunday, 9:30 a.m., NFL Net, NFL+


Money Line: Vikings (-195); Browns (+165)
Total: 35.5; Opened: 37.5
FPI favorite: Vikings by 4.8 with a 63.03% probability to win the game outright


Las Vegas Raiders vs. Indianapolis Colts -6.5
Sunday, 1 p.m., FOX


Money Line: Raiders (+240); Colts (-290)
Total: 47.5; Opened: 48.5
FPI favorite: Colts by 5.3 with a 64.07% probability to win the game outright


Dallas Cowboys -2.5 vs. New York Jets
Sunday, 1 p.m., FOX


Money Line: Cowboys (-140); Jets (+120)
Total: 47.5; Opened: 44.5
FPI favorite: Cowboys by 3.5 with a 58.6% probability to win the game outright


Denver Broncos vs. Philadelphia Eagles -3.5
Sunday, 1 p.m., CBS


Line movement: Opened Eagles -5.5

Money Line: Broncos (+165); Eagles (-195)
Total: 43.5; Opened: 44.5
FPI favorite: Eagles by 4.2 with a 61.33% probability to win the game outright


Miami Dolphins -1.5 vs. Carolina Panthers
Sunday, 1 p.m., FOX


Money Line: Dolphins (-120); Panthers (+100)
Total: 44.5; Opened: 44.5
FPI favorite: Panthers by 0.5 with a 51.53% probability to win the game outright


Houston Texans -2.5 vs. Baltimore Ravens
Sunday, 1 p.m., CBS, CBS


Line movement: Opened Ravens -3.5

Money Line: Texans (-130); Ravens (+110)
Total: 40.5; Opened: 43.5
FPI favorite: Ravens by 2.2 with a 56.17% probability to win the game outright


New York Giants vs. New Orleans Saints -1.5
Sunday, 1 p.m., CBS


Line movement: Opened Giants -2.5

Money Line: Giants (+110); Saints (-130)
Total: 41.5; Opened: 42.5
FPI favorite: Saints by 1.4 with a 53.73% probability to win the game outright


Tennessee Titans vs. Arizona Cardinals -7.5
Sunday, 4:05 p.m., CBS


Money Line: Titans (+320); Cardinals (-425)
Total: 42.5; Opened: 42.5
FPI favorite: Cardinals by 9.7 with a 73.53% probability to win the game outright


Tampa Bay Buccaneers vs. Seattle Seahawks -3.5
Sunday, 4:05 p.m., CBS


Money Line: Buccaneers (+165); Seahawks (-195)
Total: 44.5; Opened: 44.5
FPI favorite: Seahawks by 1.5 with a 54.07% probability to win the game outright


Washington Commanders vs. Los Angeles Chargers -2.5
Sunday, 4:25 p.m., FOX


Money Line: Commanders (+125); Chargers (-145)
Total: 48.5; Opened: 49.5
FPI favorite: Chargers by 3.1 with a 58.4% probability to win the game outright


Detroit Lions -10.5 vs. Cincinnati Bengals
Sunday, 4:25 p.m., FOX


Line movement: Opened Lions -8.5

Money Line: Lions (-650); Bengals (+425)
Total: 49.5; Opened: 48.5
FPI favorite: Lions by 11 with a 77% probability to win the game outright


New England Patriots vs. Buffalo Bills -7.5
Sunday, 8:20 p.m., NBC


Money Line: Patriots (+340); Bills (-450)
Total: 48.5; Opened: 49.5
FPI favorite: Bills by 7.2 with a 67.67% probability to win the game outright


Kansas City Chiefs -3.5 vs. Jacksonville Jaguars
Monday, 8:15 p.m., ABC, ESPN


Money Line: Chiefs (-190); Jaguars (+160)
Total: 46.5; Opened: 45.5
FPI favorite: Chiefs by 5.1 with a 62.93% probability to win the game outright



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